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Klinische Studien – Teil 2. Daten kritisch bewerten können

C.C. Stülpnagel, M. Augustin, R. Sommer

Der Deutsche Dermatologe 2021; 69 (3): 36-42

 

Klinische Studien liefern eine Menge an Daten. Wie kommen sie zustande und wie sind sie zu interpretieren? Dieser Beitrag stellt die Grundlagen aus Epidemiologie und klinischer Forschung vor. Teil zwei folgt dann in der März-Ausgabe des "Deutschen Dermatologen" und informiert über wichtige Studienarten.

Effects of secukinumab on disease burden, patient needs and benefits, and treatment satisfaction in patients with plaque psoriasis across european regions: Patient’s perspective data from the PROSE study

N. da Silva, R. Sommer, C-E. Ortmann, P. Jagiello, T. Bachhuber, M. Augustin (2021, April).

ePoster presented at 51. Jahrestagung der Deutschen Dermatologischen Gesellschaft (DDG-Tagung), Berlin, Germany. [Virtual].

Skin Lesions, Skin Care, and Characteristics of Pruritus in Patients Undergoing Haemodialysis

R. Sommer1, S. Ständer2, M. Augustin1

1Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany

2Department of Dermatology and Center for Chronic Pruritus, University Hospital of Münster, Münster, Germany

Skin Pharmacol Physiol. 2021 Sep 14

 

Pruritus has been shown to be a common and burdensome complaint in the general population. In some diseases, there is an even higher rate and intensity of pruritus such as in chronic kidney diseases. In particular, patients re- quiring dialysis commonly suffer from pruritus with propor- tions between 22.0 and 90.0%. Few data on the characteris- tics and burden of such pruritus have been published. There- fore, the aim of this study was to investigate the extent and profiles of pruritus in such patients related to skin lesions and care.

PMID:
Epub ahead of print. 34521094
DOI:
10.1159/000519367

Topologie der Psoriasis. Eine Prävalenzanalyse aus Real-World-Daten im Längs- und Querschnitt

C. Sorbe, R. Sommer, N. Kirsten, A. Danckworth, L.  Kühl, M. Augustin

Haut 2021; 32 (5): 212-214

Disease severity and patient needs/benefits in genital psoriasis: Patient-reported improvement after 6±1 months of Apremilast treatment

N. da Silva, R. Sommer, L. Mellars, C. von Stülpnagel, M. Cordey, M. Augustin (2021, November)

ePoster presented at 13th International Congress of Dermatology (ICD 2021) [Virtual].

Assessing the quality of life of people with chronic wounds by using the cross-culturally valid and revised Wound-QoL questionnaire

C.C. von Stülpnagel1, N. da Silva1, M. Augustin1, C. van Montfrans2, C. Fife3,4, A-M. Fagerdahl5, A. Gamus6, T. M. Klein1, C. Blome1, R. Sommer1

1German Center for Health Services Research in Dermatology (CVderm), Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg- Eppendorf (UKE), Hamburg, Germany

2Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands

3Baylor College of Medicine, Houston, Texas 4The U.S. Wound Registry, Woodlands, Texas

5Department of Clinical Science and Education, Wound Centre, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden

6Maccabi Health Services, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Wound Repair Regen. 2021 May;29(3):452-459

 

The Wound-QoL is an often used reliable and valid measure, originally developed in Germany. It has been sequentially translated and validated for other languages/coun- tries, for the measurement of health-related quality of life (HRQoL) in patients with chronic wounds. However, a study from the United States postulated its benefits from further adaptations. Furthermore, some patients struggled to provide an answer for some of the items. We aimed to test the cross-cultural structure and psychometric per- formance of the questionnaire to suggest necessary revisions.

PMID:
Epub 2021 Feb 17. 33595907
DOI:
10.1111/wrr.12901

Patients’ and physicians’ perspectives on body surface area affected by psoriasis: Links between disease burden, patient-physician (dis)agreement and patient benefits

N. da Silva, M. Augustin, C. Hilbring, C. von Stülpnagel, R. Sommer (2021, April). 
 

ePoster presented at 51. Jahrestagung der Deutschen Dermatologischen Gesellschaft (DDG-Tagung), Berlin, Germany. [Virtual].

Significance of chronic pruritus for intrapersonal burden and interpersonal experiences of stigmatization and sexuality in patients with psoriasis

R. Sommer1, M. Augustin1, C. Hilbring1, S. Ständer2, M. Hubo3, H.J. Hutt3, C.C. von Stülpnagel1, N. da Silva1

1German Center for Health Services Research in Dermatology (CVderm), Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany

2Kompetenzzentrum Chronischer Pruritus, Universita ̈tsklinikum Mu ̈nster (UKM), Mu ̈nster, Germany

3LEO Pharma GmbH, Neu-Isenburg, Germany

J Eur Acad Dermatol Venereol. 2021 Jul;35(7):1553-1561

 

60–90% of patients with psoriasis suffer from pruritus and 65% report itching as one of the most burden- some symptoms, raising significant quality of life (QoL) impairments. However, pruritus is not only an intrapersonal symptom but also a psychosocial interactive phenomenon and little is known about the effects of itching on interpersonal experiences.

Objectives: This study aimed to compare the disease burden and patient needs between patients with none/mild vs. moderate/severe pruritus, and to examine the impact of disease parameters and intrapersonal burden on perceived stigmatization and sexual relationships.

PMID:
Epub 2021 Mar 29. 33630357
DOI:
10.1111/jdv.17188

Interpersonal experiences of stigmatization and sexual impairments, quality of life and depression in patients with psoriasis: The mediating role of social avoidance coping

N. da Silva, M. Augustin, D. Wilsmann-Theis, P. Staubach-Renz, C. von Stülpnagel (2021, September-October).

ePoster presented at 30th European Academy of Dermatology and Venereology (EADV) Congress [Virtual].

Exploring the burden of xerosis cutis and the impact of dermatological skin care from patient's perspective

C. C. von Stülpnagel1, M. Augustin1, N. da Silva1, L. Schmidt2, G.Nippel2, R. Sommer1

1Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany

2Beiersdorf AG, Hamburg, Germany

J Dermatolog Treat. 2021 Sep 21:1-6

 

Xerosis cutis is recognized as a burdensome and stressful condition of the skin, resulting in impaired health-related quality of life (HRQoL). Therefore, it should be treated as a relevant skin disease with detailed care and treatment recommendations.

PMID:
34547964
DOI:
10.1080/09546634.2021.1970704
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